SUPT20H

Across TCGA cell cohorts, SUPT20H mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. CNS shows the largest number of these associations.

The most reproducible SUPT20H-associated genes across cancer lineages are GHRHR, GFRAL, and TMSB4Y. Each is linked with SUPT20H in more than 1 cancer types. Because this analysis shows association rather than direction, both SUPT20H-to-partner and partner-to-SUPT20H results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GHRHR grouped by SUPT20H-low versus SUPT20H-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SUPT20H→partner) and Y-score (partner→SUPT20H) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GHRHR →	+0.453	+5.121	<.001	<.001	3	1
BLOOD_Leukemia	GFRAL →	+0.020	+4.984	<.001	.002	3	1
LARGE_INTESTINE	TMSB4Y →	+1.526	+3.556	<.001	.007	3	1
LARGE_INTESTINE	CFHR2 →	+0.032	+3.700	<.001	.009	3	1
CNS	WNT1 →	+0.167	+3.975	.003	.005	3	1
CNS	VAX1 →	+0.513	+3.560	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

GHRHR by SUPT20H expression — BLOOD_Leukemia

Explore this box plot interactively →