SUPT16H

Across TCGA patient cohorts, SUPT16H mutation is significantly associated with the RNA expression of many other genes, with 3,492 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SUPT16H-associated genes across cancer lineages are H2AZ1, GEMIN4, and TIMM44. Each is linked with SUPT16H in more than 3 cancer types. Because this analysis shows association rather than direction, both SUPT16H-to-partner and partner-to-SUPT16H results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, H2AZ1 grouped by SUPT16H-low versus SUPT16H-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SUPT16H→partner) and Y-score (partner→SUPT16H) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	H2AZ1 →	+0.639	+1.890	<.001	<.001	3	4
STAD	GEMIN4 →	+0.793	+3.334	<.001	.005	3	4
STAD	TIMM44 →	+0.572	+3.371	<.001	.004	3	4
UCEC	ABCG2 →	-0.492	-1.637	.002	.001	3	4
UCEC	GOT1 →	+0.308	+1.701	.005	<.001	3	4
UCEC	EIF2S1 →	+0.560	+2.131	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,492 associations by consensus.

H2AZ1 by SUPT16H expression — UCEC

Explore this box plot interactively →