SUPT16H

Across TCGA patient cohorts, SUPT16H mutation is significantly associated with the total protein of many other genes, with 56 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SUPT16H-associated genes across cancer lineages are MEK1, Caspase-7-cleavedD198, and ACC1. Each is linked with SUPT16H in more than 2 cancer types. Because this analysis shows association rather than direction, both SUPT16H-to-partner and partner-to-SUPT16H results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by SUPT16H-low versus SUPT16H-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SUPT16H→partner) and Y-score (partner→SUPT16H) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.567	+2.321	<.001	<.001	3	3
COAD	Caspase-7-cleavedD198 →	+1.499	+3.008	<.001	.019	3	3
UCEC	ACC1 →	+0.329	+2.235	.005	.005	3	3
BLCA	FASN →	+0.796	+3.169	.002	.018	2	3
BLCA	mTOR_pS2448 →	-0.169	-3.169	.038	.019	3	2
COAD	PKC-a_pS657 →	-0.318	-2.991	.047	.036	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 56 associations by consensus.

MEK1 by SUPT16H expression — UCEC

Explore this box plot interactively →