SUPT16H

Across TCGA cell cohorts, SUPT16H mutation is significantly associated with the RNA expression of many other genes, with 187 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SUPT16H-associated genes across cancer lineages are CENPVL1, WFDC1, and OR11H1. Each is linked with SUPT16H in more than 1 cancer types. Because this analysis shows association rather than direction, both SUPT16H-to-partner and partner-to-SUPT16H results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CENPVL1 grouped by SUPT16H-low versus SUPT16H-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SUPT16H→partner) and Y-score (partner→SUPT16H) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CENPVL1 →	+0.259	+4.234	.001	.003	3	2
BLOOD_Lymphoma	WFDC1 →	+0.656	+2.745	.007	.007	3	1
BLOOD_Lymphoma	OR11H1 →	+0.015	+3.421	<.001	.001	3	1
BLOOD_Lymphoma	SLC35F4 →	+0.533	+3.770	.005	<.001	3	1
BLOOD_Lymphoma	ASB11 →	+0.019	+2.765	.007	.002	3	1
BLOOD_Lymphoma	OR2D2 →	+0.030	+3.115	.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 187 associations by consensus.

CENPVL1 by SUPT16H expression — BLOOD_Leukemia

Explore this box plot interactively →