SUOX

Across TCGA patient cohorts, SUOX mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SUOX-associated genes across cancer lineages are ER-alpha_pS118, Heregulin, and JNK2. Each is linked with SUOX in more than 1 cancer types. Because this analysis shows association rather than direction, both SUOX-to-partner and partner-to-SUOX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ER-alpha_pS118 grouped by SUOX-low versus SUOX-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SUOX→partner) and Y-score (partner→SUOX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	ER-alpha_pS118 →	+0.155	+2.824	.049	.036	3	1
UCEC	Heregulin →	-0.114	-1.700	.030	.044	3	1
UCEC	JNK2 →	+0.315	+3.026	<.001	.018	3	1
UCEC	Ku80 →	+0.299	+2.472	.002	.010	3	1
UCEC	p62 Lck ligand →	+0.372	+3.331	.007	.005	3	1
UCEC	Annexin-1 →	+0.527	+2.189	.018	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

ER-alpha_pS118 by SUOX expression — SKCM

Explore this box plot interactively →