SUN5

Across TCGA cell cohorts, SUN5 mutation is significantly associated with the RNA expression of many other genes, with 28 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SUN5-associated genes across cancer lineages are OR10K1, SPAG11A, and MRGPRX2. Each is linked with SUN5 in more than 1 cancer types. Because this analysis shows association rather than direction, both SUN5-to-partner and partner-to-SUN5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10K1 grouped by SUN5-low versus SUN5-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SUN5→partner) and Y-score (partner→SUN5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR10K1 →	+0.004	+3.362	<.001	.007	3	1
LUNG_NSCLC_LUAD	SPAG11A →	+0.086	+3.604	<.001	.004	3	1
LUNG_NSCLC_LUAD	MRGPRX2 →	+0.033	+4.415	<.001	<.001	3	1
LUNG_NSCLC_LUAD	MFRP →	+0.009	+4.415	.001	<.001	3	1
LUNG_NSCLC_LUAD	OR7E24 →	+0.003	+4.266	<.001	.004	3	1
LUNG_NSCLC_LUAD	MTRNR2L10 →	+0.006	+4.266	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

OR10K1 by SUN5 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →