SUN2

Across TCGA patient cohorts, SUN2 mutation is significantly associated with the RNA expression of many other genes, with 3,353 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SUN2-associated genes across cancer lineages are OR52J2P, RN7SL248P, and UHRF1. Each is linked with SUN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SUN2-to-partner and partner-to-SUN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR52J2P grouped by SUN2-low versus SUN2-high in PRAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SUN2→partner) and Y-score (partner→SUN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PRAD	OR52J2P →	+0.054	+4.897	<.001	.005	3	2
UCEC	RN7SL248P →	+0.060	+3.137	<.001	<.001	3	2
UCEC	UHRF1 →	+0.955	+2.212	<.001	<.001	3	2
UCEC	TRAC →	+1.044	+1.885	<.001	.001	3	2
UCEC	COX15 →	+0.562	+2.201	<.001	<.001	3	2
UCEC	EI24 →	+0.427	+2.584	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,353 associations by consensus.

OR52J2P by SUN2 expression — PRAD

Explore this box plot interactively →