SUN1

Across TCGA pan-cancer cohorts, SUN1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SUN1 data layer compared with 28 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SUN1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SUN1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and COAD show a favorable association.

HNSC, COAD, and LUAD are the cancer types where SUN1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	All	1.000	0.915	.022	13	view →
COAD	DFS	Median	III,IV	1.000	0.894	.035	12	view →
LUAD	DFS	Quartile	III,IV	0.270	0.749	.012	9	view →
CCRCC	DFS	Quartile	III,IV	0.074	0.740	.038	3	view →
PDAC	OS	Median	IV	0.937	0.395	.026	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SUN1–HNSC (DFS)

Open the HNSC breakdown →