SUN1

Across TCGA pan-cancer cohorts, SUN1 RNA differs between tumor and matched normal tissue in 17 of 18 cancer types tested, making tumor–normal expression one of SUN1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where SUN1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SUN1 is over-expressed in tumor, although a few such as THCA and BRCA show the opposite, repressed pattern.

HNSC, LUAD, and COAD are the cancer types where SUN1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SUN1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.880	<.001	11	view →
LUAD	All	II,III,IV	+0.511	<.001	10	view →
COAD	Male	All	+0.478	<.001	10	view →
LIHC	Female	II,III,IV	+1.200	<.001	7	view →
BLCA	All	All	+0.580	.001	7	view →
THCA	All	II,III,IV	−0.408	.001	7	view →
BRCA	All	III,IV	−0.495	<.001	6	view →
CHOL	All	All	+1.564	<.001	5	view →
STAD	Male	II,III,IV	+0.780	.017	4	view →
LUSC	Male	All	+0.703	<.001	4	view →
KIRP	All	IV	+1.094	<.001	3	view →
KIRC	All	All	+0.247	.003	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 17 lineages.

SUN1–HNSC

Open the HNSC breakdown →