SUN1

Across TCGA patient cohorts, SUN1 mutation is significantly associated with the RNA expression of many other genes, with 3,858 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SUN1-associated genes across cancer lineages are ZIC5, OR4G2P, and RNU2-15P. Each is linked with SUN1 in more than 4 cancer types. Because this analysis shows association rather than direction, both SUN1-to-partner and partner-to-SUN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZIC5 grouped by SUN1-low versus SUN1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SUN1→partner) and Y-score (partner→SUN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ZIC5 →	+0.520	+1.327	.009	.009	3	5
HNSC	OR4G2P →	+0.016	+4.178	<.001	.007	3	3
HNSC	RNU2-15P →	+0.128	+5.038	<.001	.002	3	3
BRCA	RN7SL132P →	+0.155	+5.473	.007	.005	3	3
UCEC	BAG3 →	+0.598	+2.050	<.001	<.001	3	3
UCEC	FN3K →	+0.395	+2.415	.004	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,858 associations by consensus.

ZIC5 by SUN1 expression — UCEC

Explore this box plot interactively →