SUN1

Across TCGA cell cohorts, SUN1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,578 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SUN1-associated GO terms across cancer lineages are Meiotic telomere clustering, Meiotic attachment of telomere to nuclear envelope, and Meiotic telomere tethering at nuclear periphery. Each is linked with SUN1 in more than 18 cancer types. Because this analysis shows association rather than direction, both SUN1-to-partner and partner-to-SUN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Meiotic telomere clustering grouped by SUN1-low versus SUN1-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SUN1→partner) and Y-score (partner→SUN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Meiotic telomere clustering →	+0.218	+1.403	<.001	<.001	3	19
BLOOD_Leukemia	Meiotic attachment of telomere to nuclear envelope →	+0.218	+1.403	<.001	<.001	3	19
BLOOD_Leukemia	Meiotic telomere tethering at nuclear periphery →	+0.218	+1.403	<.001	<.001	3	19
BLOOD_Leukemia	Chromosome localization to nuclear envelope involved in homologous chromosome segregation →	+0.297	+1.226	<.001	<.001	3	17
OESOPHAGUS	Vesicle-mediated transport to the plasma membrane →	+0.071	+1.139	.006	<.001	3	14
LARGE_INTESTINE	Protein stabilization →	+0.054	+1.001	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,578 associations by consensus.

Meiotic telomere clustering by SUN1 expression — BLOOD_Leukemia

Explore this box plot interactively →