SUN1

Across TCGA cell cohorts, SUN1 mutation is significantly associated with the RNA expression of many other genes, with 312 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SUN1-associated genes across cancer lineages are TRAT1, CPN1, and SAXO1. Each is linked with SUN1 in more than 3 cancer types. Because this analysis shows association rather than direction, both SUN1-to-partner and partner-to-SUN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRAT1 grouped by SUN1-low versus SUN1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SUN1→partner) and Y-score (partner→SUN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TRAT1 →	+2.926	+3.977	<.001	<.001	3	4
BLOOD_Leukemia	CPN1 →	+0.088	+3.083	.002	.003	3	2
BLOOD_Leukemia	SAXO1 →	+0.033	+3.518	.003	.008	3	2
BLOOD_Leukemia	INSM2 →	+0.148	+3.354	<.001	.001	3	2
BLOOD_Leukemia	C1QTNF9 →	+0.032	+3.174	<.001	.004	3	2
LARGE_INTESTINE	BBS7 →	+0.561	+3.212	.009	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 312 associations by consensus.

TRAT1 by SUN1 expression — BLOOD_Leukemia

Explore this box plot interactively →