SUFU

Across TCGA pan-cancer cohorts, SUFU mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of SUFU’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where SUFU mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types SUFU is over-expressed in tumor, although a few such as LUAD and HNSC show the opposite, repressed pattern.

LUAD, HNSC, and LSCC are the cancer types where SUFU tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SUFU mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Male	II,III,IV	−0.261	<.001	9	view →
HNSC	Male	All	−0.166	.005	8	view →
LSCC	Male	III,IV	−0.254	.001	6	view →
CCRCC	All	All	+0.215	.005	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

SUFU–LUAD

Open the LUAD breakdown →