SUFU

Across TCGA pan-cancer cohorts, SUFU RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated SUFU data layer compared with 7 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher SUFU RNA is associated with better overall survival. In most high-consensus cancer types, elevated SUFU expression acts as an unfavorable survival marker, although some lineages such as KIRC and LGG show a favorable association.

KIRC, ACC, and LGG are the cancer types where SUFU RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.724	0.536	<.001	98	view →
ACC	DFS	Median	All	0.381	0.775	<.001	85	view →
LGG	DFS	Median	All	0.808	0.654	<.001	46	view →
OV	OS	Median	III,IV	0.271	0.357	.004	40	view →
HNSC	DFS	Quartile	All	0.463	0.258	.004	37	view →
SCLC	DFS	Median	II,III,IV	0.833	0.190	<.001	25	view →
UCEC	DFS	Median	IV	0.812	0.530	.006	24	view →
UCS	OS	Median	IV	0.732	0.224	.018	22	view →
KIRP	OS	Median	II,III,IV	0.810	0.278	.014	21	view →
LAML	DFS	Quartile	All	0.461	0.651	.018	14	view →
LIHC	DFS	Quartile	All	0.340	0.489	.018	13	view →
LUSC	DFS	Tertile	III,IV	0.379	0.935	.006	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

SUFU–KIRC (OS)

Open the KIRC breakdown →