SUFU

Across TCGA patient cohorts, SUFU protein abundance is significantly associated with the RNA expression of many other genes, with 7,890 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SUFU-associated genes across cancer lineages are JAM3, ACTA2, and CNRIP1. Each is linked with SUFU in more than 6 cancer types. Because this analysis shows association rather than direction, both SUFU-to-partner and partner-to-SUFU results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SUFU versus JAM3 in BRCA, with a Pearson correlation of 0.33.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SUFU→partner) and Y-score (partner→SUFU) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	JAM3 →	+0.817	+0.350	<.001	<.001	3	7
BRCA	ACTA2 →	+1.468	+0.347	<.001	<.001	3	6
UCEC	CNRIP1 →	+0.755	+0.258	.005	.002	3	6
COAD	MSRB3 →	+1.608	+0.581	.001	.003	3	6
UCEC	CYS1 →	+0.996	+0.241	<.001	<.001	3	6
COAD	SCARF2 →	+1.336	+0.581	<.001	.004	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,890 associations by consensus.

SUFU vs JAM3 — BRCA

Explore this scatter interactively →