SUFU

Across TCGA patient cohorts, SUFU mutation is significantly associated with the RNA expression of many other genes, with 2,434 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SUFU-associated genes across cancer lineages are RN7SKP295, SNORA10B, and ATP6V1E1P2. Each is linked with SUFU in more than 2 cancer types. Because this analysis shows association rather than direction, both SUFU-to-partner and partner-to-SUFU results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP295 grouped by SUFU-low versus SUFU-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SUFU→partner) and Y-score (partner→SUFU) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SKP295 →	+0.140	+2.171	.003	.006	3	3
SKCM	SNORA10B →	+0.186	+3.564	<.001	.005	3	3
UCEC	ATP6V1E1P2 →	+0.098	+1.907	.009	.003	3	2
LIHC	BRI3P2 →	+0.071	+5.149	.008	.003	3	2
LIHC	SEPTIN14P24 →	+0.212	+4.544	<.001	.009	3	2
LIHC	RPS6P2 →	+0.047	+5.149	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,434 associations by consensus.

RN7SKP295 by SUFU expression — UCEC

Explore this box plot interactively →