SUFU

Across TCGA patient cohorts, SUFU mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SUFU-associated genes across cancer lineages are eIF4E, Rictor_pT1135, and ATM. Each is linked with SUFU in more than 1 cancer types. Because this analysis shows association rather than direction, both SUFU-to-partner and partner-to-SUFU results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by SUFU-low versus SUFU-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SUFU→partner) and Y-score (partner→SUFU) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.184	+3.183	.026	.009	3	2
UCEC	Rictor_pT1135 →	-0.124	-2.502	.002	.002	3	2
UCEC	ATM →	-0.600	-2.502	<.001	.002	3	2
UCEC	Cyclin-E2 →	+0.165	+2.232	.012	.005	3	2
UCEC	EGFR_pY1068 →	-0.227	-2.000	.021	.010	3	1
UCEC	eIF4G →	+0.315	+2.115	.009	.017	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

eIF4E by SUFU expression — UCEC

Explore this box plot interactively →