SUFU

Across TCGA cell cohorts, SUFU RNA expression is significantly associated with the go_rna of many other GO terms, with 4,667 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SUFU-associated GO terms across cancer lineages are Negative regulation of smoothened signaling pathway, Regulation of sister chromatid cohesion, and Regulation of smoothened signaling pathway. Each is linked with SUFU in more than 13 cancer types. Because this analysis shows association rather than direction, both SUFU-to-partner and partner-to-SUFU results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of smoothened signaling pathway grouped by SUFU-low versus SUFU-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SUFU→partner) and Y-score (partner→SUFU) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Negative regulation of smoothened signaling pathway →	+0.066	+0.776	<.001	<.001	3	14
SOFT_TISSUE	Regulation of sister chromatid cohesion →	+0.094	+0.492	<.001	<.001	3	14
OVARY	Regulation of smoothened signaling pathway →	+0.055	+0.689	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Viral translational termination-reinitiation →	+0.087	+0.744	.001	<.001	3	13
URINARY_TRACT	Regulation of telomere capping →	+0.088	+0.542	.003	.002	3	12
LUNG_NSCLC_LUSC	Regulation of chromosome organization →	+0.089	+0.812	.002	.003	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,667 associations by consensus.

Negative regulation of smoothened signaling pathway by SUFU expression — STOMACH

Explore this box plot interactively →