SUFU

Across TCGA cell cohorts, SUFU mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SUFU-associated genes across cancer lineages are HCRTR2, ASB17, and MMP26. Each is linked with SUFU in more than 1 cancer types. Because this analysis shows association rather than direction, both SUFU-to-partner and partner-to-SUFU results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HCRTR2 grouped by SUFU-low versus SUFU-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SUFU→partner) and Y-score (partner→SUFU) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	HCRTR2 →	+0.050	+3.347	.003	.005	3	1
LARGE_INTESTINE	ASB17 →	+0.015	+3.632	<.001	.003	3	1
LARGE_INTESTINE	MMP26 →	+0.039	+3.632	<.001	.003	3	1
LARGE_INTESTINE	GPR171 →	+0.013	+3.688	.004	.002	3	1
LARGE_INTESTINE	PRAMEF33 →	+0.076	+4.022	<.001	.006	3	1
LARGE_INTESTINE	DGKK →	+0.344	+3.736	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

HCRTR2 by SUFU expression — LARGE_INTESTINE

Explore this box plot interactively →