SUCLG1

Across TCGA patient cohorts, SUCLG1 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SUCLG1-associated genes across cancer lineages are INPP4B, Lck, and MSH2. Each is linked with SUCLG1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SUCLG1-to-partner and partner-to-SUCLG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by SUCLG1-low versus SUCLG1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SUCLG1→partner) and Y-score (partner→SUCLG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INPP4B →	-0.311	-3.321	.039	.009	3	1
UCEC	Lck →	+0.232	+3.000	.013	.036	3	1
UCEC	MSH2 →	-0.268	-2.973	.012	.035	3	1
UCEC	NF-kB-p65_pS536 →	-0.483	-2.990	.022	.036	3	1
UCEC	p62 Lck ligand →	+0.481	+2.584	.001	.011	3	1
UCEC	P-Cadherin →	-0.134	-3.159	.045	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

INPP4B by SUCLG1 expression — UCEC

Explore this box plot interactively →