SUCLG1

Across TCGA pan-cancer cohorts, SUCLG1 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of SUCLG1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where SUCLG1 RNA is repressed in tumor relative to normal tissue. In most cancer types SUCLG1 is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

KIRC, KIRP, and THCA are the cancer types where SUCLG1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SUCLG1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	−1.580	<.001	11	view →
KIRP	All	III,IV	−1.211	<.001	11	view →
THCA	Male	III,IV	−1.067	<.001	11	view →
COAD	Male	All	−0.628	<.001	11	view →
KICH	Female	II,III,IV	−1.540	<.001	9	view →
BRCA	Female	All	−0.525	<.001	6	view →
HNSC	All	II,III,IV	−0.251	.001	4	view →
BLCA	Male	III,IV	−0.538	.002	3	view →
LIHC	All	All	+0.344	<.001	3	view →
PRAD	All	All	−0.330	<.001	2	view →
LUSC	Male	All	+0.294	.001	2	view →
READ	All	All	−0.683	.004	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

SUCLG1–KIRC

Open the KIRC breakdown →