STYXL1

Across TCGA pan-cancer cohorts, STYXL1 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated STYXL1 data layer compared with 29 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher STYXL1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated STYXL1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

COAD, UCEC, and SKCM are the cancer types where STYXL1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Median	All	0.170	0.683	.001	14	view →
UCEC	DFS	Median	All	1.000	0.631	.020	10	view →
SKCM	DFS	Median	II,III,IV	0.839	0.248	.012	9	view →
PRAD	DFS	Median	All	0.144	0.888	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

STYXL1–COAD (OS)

Open the COAD breakdown →