STYXL1

Across TCGA pan-cancer cohorts, STYXL1 RNA differs between tumor and matched normal tissue in 17 of 18 cancer types tested, making tumor–normal expression one of STYXL1’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where STYXL1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types STYXL1 is over-expressed in tumor.

BLCA, LIHC, and LUAD are the cancer types where STYXL1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in STYXL1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	All	III,IV	+1.057	<.001	11	view →
LIHC	Male	All	+1.050	<.001	9	view →
LUAD	All	III,IV	+0.906	<.001	9	view →
HNSC	Male	All	+0.544	<.001	8	view →
BRCA	All	III,IV	+0.841	<.001	6	view →
STAD	All	II,III,IV	+0.638	<.001	6	view →
COAD	Male	All	+0.615	<.001	6	view →
CHOL	Male	All	+1.616	<.001	5	view →
LUSC	Female	All	+0.702	<.001	5	view →
KIRP	All	All	+0.402	.003	5	view →
ESCA	All	All	+0.759	.003	3	view →
KICH	Male	IV	+0.733	.010	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 17 lineages.

STYXL1–BLCA

Open the BLCA breakdown →