STYXL1

Across TCGA patient cohorts, STYXL1 mutation is significantly associated with the RNA expression of many other genes, with 1,700 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STYXL1-associated genes across cancer lineages are OR4M1, COX15, and NCAPD3. Each is linked with STYXL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both STYXL1-to-partner and partner-to-STYXL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4M1 grouped by STYXL1-low versus STYXL1-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STYXL1→partner) and Y-score (partner→STYXL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	OR4M1 →	+0.026	+5.342	<.001	.002	3	2
SKCM	COX15 →	+0.679	+3.232	<.001	.008	3	2
UCEC	NCAPD3 →	+0.712	+2.708	<.001	.003	3	2
UCEC	CENPU →	+0.971	+2.949	<.001	<.001	3	2
UCEC	GPATCH11 →	+0.604	+2.950	<.001	<.001	3	2
UCEC	TBRG1 →	+0.350	+2.053	.002	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,700 associations by consensus.

OR4M1 by STYXL1 expression — CESC

Explore this box plot interactively →