STYXL1

Across TCGA cell cohorts, STYXL1 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible STYXL1-associated genes across cancer lineages are MDGA2, UNC45B, and MS4A10. Each is linked with STYXL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both STYXL1-to-partner and partner-to-STYXL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MDGA2 grouped by STYXL1-low versus STYXL1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STYXL1→partner) and Y-score (partner→STYXL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MDGA2 →	+0.170	+3.854	<.001	.006	3	1
LARGE_INTESTINE	UNC45B →	+0.005	+3.684	<.001	.006	3	1
LARGE_INTESTINE	MS4A10 →	+0.010	+3.684	.001	.006	3	1
LARGE_INTESTINE	MAGEB10 →	+0.083	+3.930	<.001	.003	3	1
LARGE_INTESTINE	IFNL2 →	+0.403	+3.938	<.001	.005	3	1
LARGE_INTESTINE	IFNL4 →	+0.015	+3.684	.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

MDGA2 by STYXL1 expression — LARGE_INTESTINE

Explore this box plot interactively →