Across TCGA patient cohorts, STYX mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STYX-associated genes across cancer lineages are EGFR_pY1068, eIF4E, and A-Raf_pS299. Each is linked with STYX in more than 1 cancer types. Because this analysis shows association rather than direction, both STYX-to-partner and partner-to-STYX results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STYX→partner) and Y-score (partner→STYX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.295	-2.807	.001	<.001	3	1
UCEC	eIF4E →	+0.187	+2.472	.014	.010	3	1
UCEC	A-Raf_pS299 →	-0.129	-2.115	.002	.017	3	1
UCEC	FOXO3a_pS318_S321 →	-0.119	-1.990	.007	.009	3	1
UCEC	GATA6 →	-0.126	-2.307	.033	.033	3	1
UCEC	JNK_pT183_Y185 →	-0.154	-1.700	.011	.042	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

Exploration

STYX survival (RNA) · tumor vs normal (RNA) · all STYX data types