STXBP5L

Across TCGA patient cohorts, STXBP5L mutation is significantly associated with the RNA expression of many other genes, with 4,705 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STXBP5L-associated genes across cancer lineages are SCNN1B, SF3B6, and DCLRE1B. Each is linked with STXBP5L in more than 4 cancer types. Because this analysis shows association rather than direction, both STXBP5L-to-partner and partner-to-STXBP5L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SCNN1B grouped by STXBP5L-low versus STXBP5L-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STXBP5L→partner) and Y-score (partner→STXBP5L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	SCNN1B →	-1.380	-3.898	<.001	<.001	3	5
SKCM	SF3B6 →	+0.274	+1.254	<.001	<.001	3	4
UCEC	DCLRE1B →	+0.450	+1.653	<.001	<.001	3	4
SKCM	SGO1 →	+0.427	+1.932	<.001	<.001	3	4
SKCM	METTL5 →	+0.210	+1.367	.005	<.001	3	4
LUSC	SUSD4 →	-1.006	-2.247	.002	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,705 associations by consensus.

SCNN1B by STXBP5L expression — LUSC

Explore this box plot interactively →