STXBP5

Across TCGA pan-cancer cohorts, STXBP5 mass-spec protein differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of STXBP5’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where STXBP5 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types STXBP5 is over-expressed in tumor, although a few such as COAD and LUAD show the opposite, repressed pattern.

COAD, LUAD, and PDAC are the cancer types where STXBP5 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in STXBP5 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	−0.179	<.001	9	view →
LUAD	Female	III,IV	−0.497	<.001	8	view →
PDAC	Female	II,III,IV	−0.370	<.001	8	view →
HNSC	Male	IV	−0.368	<.001	8	view →
LSCC	Male	III,IV	−0.350	<.001	8	view →
CCRCC	All	All	+0.321	<.001	3	view →
OV	All	All	−0.446	.036	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

STXBP5–COAD

Open the COAD breakdown →