STXBP5

Across TCGA patient cohorts, STXBP5 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STXBP5-associated genes across cancer lineages are ATM, cIAP, and Akt_pT308. Each is linked with STXBP5 in more than 2 cancer types. Because this analysis shows association rather than direction, both STXBP5-to-partner and partner-to-STXBP5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by STXBP5-low versus STXBP5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STXBP5→partner) and Y-score (partner→STXBP5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.459	-2.401	.001	.002	3	3
UCEC	cIAP →	+0.090	+1.670	.034	.001	3	3
BRCA	Akt_pT308 →	+0.518	+2.817	.027	.037	3	2
UCEC	ACC1 →	+0.332	+2.598	.003	.005	3	2
UCEC	ACVRL1 →	-0.084	-1.986	.047	.029	3	2
UCEC	p62 Lck ligand →	+0.372	+2.080	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

ATM by STXBP5 expression — UCEC

Explore this box plot interactively →