STXBP5

Across TCGA cell cohorts, STXBP5 mutation is significantly associated with the RNA expression of many other genes, with 31 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible STXBP5-associated genes across cancer lineages are TSPAN16, CCKBR, and SERTM1. Each is linked with STXBP5 in more than 1 cancer types. Because this analysis shows association rather than direction, both STXBP5-to-partner and partner-to-STXBP5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TSPAN16 grouped by STXBP5-low versus STXBP5-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STXBP5→partner) and Y-score (partner→STXBP5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	TSPAN16 →	+0.033	+3.432	<.001	.001	3	2
OESOPHAGUS	CCKBR →	+0.635	+3.662	.003	.005	3	1
OESOPHAGUS	SERTM1 →	+0.116	+3.736	<.001	.004	3	1
OESOPHAGUS	KRTAP19-1 →	+0.673	+3.115	.001	.005	3	1
OESOPHAGUS	VHLL →	+0.095	+3.675	<.001	.003	3	1
BLOOD_Myeloma	SERPINA7 →	+0.459	+4.807	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

TSPAN16 by STXBP5 expression — OESOPHAGUS

Explore this box plot interactively →