STXBP5-AS1

Across TCGA pan-cancer cohorts, STXBP5-AS1 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated STXBP5-AS1 data layer.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher STXBP5-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated STXBP5-AS1 expression acts as an unfavorable survival marker, although some lineages such as PAAD and ESCA show a favorable association.

CESC, LUAD, and KIRP are the cancer types where STXBP5-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	DFS	Quartile	All	0.369	0.736	<.001	70	view →
LUAD	DFS	Tertile	IV	0.391	0.929	<.001	70	view →
KIRP	OS	Median	III,IV	0.493	0.800	.004	66	view →
BRCA	OS	Median	All	0.494	0.645	<.001	58	view →
OV	DFS	Median	III,IV	0.120	0.190	.001	50	view →
MESO	OS	Tertile	All	0.169	0.593	.005	39	view →
PAAD	DFS	Median	All	0.378	0.196	.003	36	view →
ESCA	OS	Tertile	III,IV	0.701	0.404	.010	30	view →
ACC	DFS	Median	All	0.186	0.623	.006	30	view →
COAD	OS	Median	IV	0.708	0.352	<.001	24	view →
LAML	DFS	Quartile	All	0.667	0.243	.002	20	view →
THCA	DFS	Median	All	0.899	0.768	.002	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

STXBP5-AS1–CESC (DFS)

Open the CESC breakdown →