STXBP5-AS1

Across TCGA pan-cancer cohorts, STXBP5-AS1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of STXBP5-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where STXBP5-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types STXBP5-AS1 is over-expressed in tumor, although a few such as HNSC and LUSC show the opposite, repressed pattern.

HNSC, KIRC, and LUSC are the cancer types where STXBP5-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in STXBP5-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	−0.408	.006	7	view →
KIRC	All	All	+0.167	<.001	7	view →
LUSC	All	All	−0.157	<.001	7	view →
BRCA	All	III,IV	−0.357	<.001	6	view →
COAD	Female	III,IV	−0.674	.020	4	view →
KICH	Female	All	−0.291	<.001	4	view →
UCEC	All	All	−0.263	<.001	4	view →
LIHC	Female	II,III,IV	+0.196	<.001	4	view →
READ	All	All	−0.349	.027	2	view →
PRAD	All	All	−0.261	.015	2	view →
CHOL	All	All	+0.896	.046	1	view →
LUAD	Female	III,IV	−0.233	.015	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

STXBP5-AS1–HNSC

Open the HNSC breakdown →