STXBP2

Across TCGA patient cohorts, STXBP2 mutation is significantly associated with the RNA expression of many other genes, with 1,276 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STXBP2-associated genes across cancer lineages are MIR4418, RNU6-77P, and WDR41. Each is linked with STXBP2 in more than 2 cancer types. Because this analysis shows association rather than direction, both STXBP2-to-partner and partner-to-STXBP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4418 grouped by STXBP2-low versus STXBP2-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STXBP2→partner) and Y-score (partner→STXBP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	MIR4418 →	+0.680	+4.401	<.001	.006	3	3
LUAD	RNU6-77P →	+2.675	+4.598	<.001	.004	3	3
COAD	WDR41 →	+0.494	+3.272	.002	.008	3	3
UCEC	WDR1 →	+0.401	+3.617	.003	.001	3	3
UCEC	TOLLIP →	+0.467	+3.742	<.001	<.001	3	3
STAD	MIR5591 →	+0.643	+4.646	.004	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,276 associations by consensus.

MIR4418 by STXBP2 expression — STAD

Explore this box plot interactively →