STXBP2

Across TCGA pan-cancer cohorts, STXBP2 RNA is linked to patient survival in 29 of 34 cancer types, making it the most broadly survival-associated STXBP2 data layer compared with 4 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in brain lower grade glioma (LGG), where higher STXBP2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated STXBP2 expression acts as an unfavorable survival marker, although some lineages such as CESC and UCEC show a favorable association.

LGG, CESC, and UCEC are the cancer types where STXBP2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	DFS	Median	All	0.287	0.497	<.001	54	view →
CESC	DFS	Tertile	III,IV	0.922	0.634	.006	50	view →
UCEC	DFS	Median	All	0.692	0.617	.001	46	view →
BLCA	OS	Quartile	All	0.707	0.478	.001	34	view →
THCA	OS	Tertile	All	0.994	0.868	.003	31	view →
CHOL	OS	Quartile	All	0.931	0.361	.005	28	view →
LIHC	DFS	Quartile	All	0.419	0.585	.005	28	view →
UCS	DFS	Quartile	II,III,IV	0.119	0.556	.002	24	view →
KIRC	DFS	Tertile	All	0.555	0.706	.011	24	view →
SARC	OS	Tertile	All	0.857	0.665	<.001	24	view →
LUAD	OS	Tertile	II,III,IV	0.575	0.322	.005	24	view →
HNSC	OS	Median	IV	0.520	0.269	<.001	22	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 29 lineages.

STXBP2–LGG (DFS)

Open the LGG breakdown →