STXBP2

Across TCGA cell cohorts, STXBP2 mutation is significantly associated with the RNA expression of many other genes, with 28 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible STXBP2-associated genes across cancer lineages are ASB17, C12orf40, and PAPOLB. Each is linked with STXBP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both STXBP2-to-partner and partner-to-STXBP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASB17 grouped by STXBP2-low versus STXBP2-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STXBP2→partner) and Y-score (partner→STXBP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	ASB17 →	+0.014	+4.222	<.001	.006	3	1
OVARY	C12orf40 →	+0.010	+4.444	<.001	.001	3	1
OVARY	PAPOLB →	+0.011	+3.791	.001	.007	3	1
SKIN	VWA5B1 →	+0.010	+2.657	<.001	.007	3	1
SKIN	INSL5 →	+0.049	+2.882	<.001	.005	3	1
SKIN	UGT2B17 →	+0.190	+2.657	.002	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

ASB17 by STXBP2 expression — OVARY

Explore this box plot interactively →