STXBP1

Across TCGA patient cohorts, STXBP1 mutation is significantly associated with the RNA expression of many other genes, with 1,850 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STXBP1-associated genes across cancer lineages are CXCL9, LINC00869, and RNU6-993P. Each is linked with STXBP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both STXBP1-to-partner and partner-to-STXBP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CXCL9 grouped by STXBP1-low versus STXBP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STXBP1→partner) and Y-score (partner→STXBP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CXCL9 →	+1.978	+2.432	<.001	<.001	3	3
UCEC	LINC00869 →	-0.414	-2.051	<.001	<.001	3	2
CESC	RNU6-993P →	+0.238	+4.075	<.001	.001	3	2
ESCA	MIR4690 →	+0.815	+5.450	<.001	.004	3	2
ESCA	KRTAP12-6P →	+0.215	+5.247	<.001	.006	3	2
LIHC	ACTR3P2 →	+0.035	+4.589	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,850 associations by consensus.

CXCL9 by STXBP1 expression — UCEC

Explore this box plot interactively →