STXBP1

Across TCGA pan-cancer cohorts, STXBP1 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of STXBP1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where STXBP1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types STXBP1 is over-expressed in tumor, although a few such as KICH and BLCA show the opposite, repressed pattern.

HNSC, COAD, and KICH are the cancer types where STXBP1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in STXBP1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+1.385	<.001	12	view →
COAD	Female	II,III,IV	+1.593	<.001	11	view →
KICH	All	III,IV	−1.434	<.001	10	view →
BLCA	Male	IV	−2.452	<.001	8	view →
READ	All	All	+1.580	<.001	7	view →
LUAD	Female	All	−0.730	<.001	7	view →
THCA	All	All	−0.436	<.001	7	view →
UCEC	All	All	−2.201	<.001	6	view →
LUSC	Female	II,III,IV	−1.971	<.001	6	view →
BRCA	All	All	−1.093	<.001	6	view →
CHOL	All	All	+1.290	.006	5	view →
LIHC	Female	All	+1.106	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

STXBP1–HNSC

Open the HNSC breakdown →