STXBP1

Across TCGA patient cohorts, STXBP1 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STXBP1-associated genes across cancer lineages are eEF2, Shc_pY317, and TSC1. Each is linked with STXBP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both STXBP1-to-partner and partner-to-STXBP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by STXBP1-low versus STXBP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STXBP1→partner) and Y-score (partner→STXBP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.336	+2.700	.006	.005	3	2
UCEC	Shc_pY317 →	-0.187	-3.807	<.001	<.001	3	2
UCEC	TSC1 →	-0.161	-2.661	.006	.005	3	2
UCEC	Caspase-7-cleavedD198 →	+0.647	+3.827	.001	<.001	3	2
UCEC	4E-BP1 →	+0.246	+1.351	.008	.042	3	2
UCEC	Di-Ras3 →	-0.104	-1.736	.042	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

eEF2 by STXBP1 expression — UCEC

Explore this box plot interactively →