STXBP1

Across TCGA cell cohorts, STXBP1 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible STXBP1-associated genes across cancer lineages are TCF21, C20orf85, and IL22. Each is linked with STXBP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both STXBP1-to-partner and partner-to-STXBP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TCF21 grouped by STXBP1-low versus STXBP1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STXBP1→partner) and Y-score (partner→STXBP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TCF21 →	+0.017	+5.121	<.001	<.001	3	1
BLOOD_Leukemia	C20orf85 →	+0.029	+4.384	<.001	.006	3	1
BLOOD_Leukemia	IL22 →	+0.030	+4.984	<.001	.002	3	1
BLOOD_Leukemia	ASZ1 →	+0.116	+4.567	<.001	.001	3	1
BLOOD_Leukemia	OR10K1 →	+0.445	+4.234	<.001	.003	3	1
BLOOD_Leukemia	SFT2D3 →	+0.699	+4.450	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

TCF21 by STXBP1 expression — BLOOD_Leukemia

Explore this box plot interactively →