STX6

Across TCGA patient cohorts, STX6 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STX6-associated genes across cancer lineages are eEF2, EGFR_pY1068, and A-Raf_pS299. Each is linked with STX6 in more than 1 cancer types. Because this analysis shows association rather than direction, both STX6-to-partner and partner-to-STX6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by STX6-low versus STX6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STX6→partner) and Y-score (partner→STX6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.453	+3.321	.002	.009	3	1
UCEC	EGFR_pY1068 →	-0.254	-2.906	.017	.001	3	1
UCEC	A-Raf_pS299 →	-0.190	-3.459	<.001	.005	3	1
UCEC	ERK2 →	+0.342	+2.906	<.001	.001	3	1
UCEC	ETS-1 →	+0.284	+3.000	.035	.036	3	1
UCEC	GATA6 →	-0.181	-2.321	.009	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

eEF2 by STX6 expression — UCEC

Explore this box plot interactively →