STX6

Across TCGA pan-cancer cohorts, STX6 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of STX6’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where STX6 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types STX6 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

HNSC, KIRC, and BLCA are the cancer types where STX6 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in STX6 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	IV	+1.316	<.001	12	view →
KIRC	Female	All	+0.511	<.001	12	view →
BLCA	Male	All	+1.123	<.001	10	view →
STAD	All	II,III,IV	+0.832	<.001	10	view →
COAD	Male	IV	+0.831	<.001	10	view →
LIHC	Female	II,III,IV	+1.397	<.001	9	view →
LUAD	Male	II,III,IV	+0.653	<.001	9	view →
LUSC	Female	All	+1.099	<.001	7	view →
UCEC	All	III,IV	+1.186	<.001	6	view →
BRCA	All	III,IV	+0.890	<.001	6	view →
KIRP	All	II,III,IV	+0.810	.001	6	view →
CHOL	Male	All	+3.271	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

STX6–HNSC

Open the HNSC breakdown →