STX6

Across TCGA cell cohorts, STX6 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,856 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible STX6-associated GO terms across cancer lineages are Epigenetic regulation of gene expression, Nuclear export, and RNA export from nucleus. Each is linked with STX6 in more than 11 cancer types. Because this analysis shows association rather than direction, both STX6-to-partner and partner-to-STX6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Epigenetic regulation of gene expression grouped by STX6-low versus STX6-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (STX6→partner) and Y-score (partner→STX6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Epigenetic regulation of gene expression →	+0.062	+0.629	.006	.009	3	11
PANCREAS	Nuclear export →	+0.084	+0.876	<.001	<.001	3	11
PANCREAS	RNA export from nucleus →	+0.101	+0.735	<.001	.002	3	11
LIVER	Positive regulation of mRNA processing →	+0.122	+0.693	.002	<.001	2	12
STOMACH	Establishment of protein localization to endoplasmic reticulum membrane →	+0.084	+0.613	.006	<.001	3	11
SOFT_TISSUE	Negative regulation of purine nucleotide biosynthetic process →	+0.178	+0.540	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,856 associations by consensus.

Epigenetic regulation of gene expression by STX6 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →