STX1B

Across TCGA patient cohorts, STX1B mutation is significantly associated with the RNA expression of many other genes, with 2,851 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STX1B-associated genes across cancer lineages are L3MBTL2, UQCRC1, and DHODH. Each is linked with STX1B in more than 1 cancer types. Because this analysis shows association rather than direction, both STX1B-to-partner and partner-to-STX1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, L3MBTL2 grouped by STX1B-low versus STX1B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STX1B→partner) and Y-score (partner→STX1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	L3MBTL2 →	+0.515	+4.004	<.001	<.001	3	2
UCEC	UQCRC1 →	+0.411	+3.600	.004	.001	3	2
UCEC	DHODH →	+0.402	+3.523	<.001	.002	3	2
UCEC	UBE2I →	+0.425	+3.732	<.001	<.001	3	2
UCEC	KNOP1 →	+0.574	+3.708	<.001	<.001	3	2
UCEC	BRAT1 →	+0.394	+2.566	.004	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,851 associations by consensus.

L3MBTL2 by STX1B expression — UCEC

Explore this box plot interactively →