STX1B

Across TCGA pan-cancer cohorts, STX1B RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of STX1B’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where STX1B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types STX1B is over-expressed in tumor, although a few such as KICH and UCEC show the opposite, repressed pattern.

THCA, KIRC, and KICH are the cancer types where STX1B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in STX1B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	IV	+0.903	<.001	11	view →
KIRC	Male	IV	+0.741	<.001	11	view →
KICH	Female	All	−0.591	<.001	10	view →
UCEC	All	All	−0.995	<.001	6	view →
BRCA	All	All	−0.423	<.001	6	view →
BLCA	Male	IV	−0.430	.011	2	view →
KIRP	All	All	+0.397	.002	2	view →
PAAD	Male	All	−0.314	.028	2	view →
LUAD	Female	All	+0.209	.030	2	view →
PRAD	All	All	−0.190	.001	2	view →
COAD	All	IV	+0.425	.038	1	view →
LIHC	Male	All	+0.319	.021	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

STX1B–THCA

Open the THCA breakdown →