STX1B

Across TCGA cell cohorts, STX1B mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible STX1B-associated genes across cancer lineages are CFHR2, KRT71, and DYNAP. Each is linked with STX1B in more than 1 cancer types. Because this analysis shows association rather than direction, both STX1B-to-partner and partner-to-STX1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CFHR2 grouped by STX1B-low versus STX1B-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STX1B→partner) and Y-score (partner→STX1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CFHR2 →	+0.076	+6.022	<.001	.001	3	2
BLOOD_Lymphoma	KRT71 →	+0.013	+5.643	<.001	.002	3	1
BLOOD_Lymphoma	DYNAP →	+0.071	+4.867	.002	.009	3	1
BLOOD_Lymphoma	KRTAP4-1 →	+0.162	+4.867	<.001	.009	3	1
LARGE_INTESTINE	TMCO5A →	+0.026	+5.415	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

CFHR2 by STX1B expression — LARGE_INTESTINE

Explore this box plot interactively →