STX1A

Across TCGA patient cohorts, STX1A mutation is significantly associated with the RNA expression of many other genes, with 302 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STX1A-associated genes across cancer lineages are MIR615, RNU6-6P, and OAZ1. Each is linked with STX1A in more than 1 cancer types. Because this analysis shows association rather than direction, both STX1A-to-partner and partner-to-STX1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR615 grouped by STX1A-low versus STX1A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STX1A→partner) and Y-score (partner→STX1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR615 →	+0.198	+2.132	.004	.009	3	2
COAD	RNU6-6P →	+0.706	+3.877	.003	.008	3	2
UCEC	OAZ1 →	+0.404	+2.075	.001	.005	3	2
SKCM	MTND1P16 →	+0.044	+4.970	<.001	.005	3	2
SKCM	OR11H2 →	+0.043	+4.513	<.001	.009	3	1
SKCM	VN1R69P →	+0.109	+5.199	.005	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 302 associations by consensus.

MIR615 by STX1A expression — UCEC

Explore this box plot interactively →