STX1A

Across TCGA pan-cancer cohorts, STX1A RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated STX1A data layer compared with 4 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher STX1A RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated STX1A expression acts as an unfavorable survival marker, although some lineages such as UCS and SCLC show a favorable association.

KIRC, MESO, and KIRP are the cancer types where STX1A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.558	0.686	<.001	154	view →
MESO	OS	Median	All	0.251	0.512	<.001	132	view →
KIRP	OS	Quartile	II,III,IV	0.553	0.900	<.001	120	view →
LUSC	DFS	Quartile	All	0.618	0.808	<.001	79	view →
LIHC	DFS	Median	All	0.452	0.629	<.001	75	view →
CESC	DFS	Median	All	0.643	0.814	<.001	74	view →
UCEC	OS	Median	All	0.608	0.764	<.001	66	view →
BRCA	DFS	Median	All	0.869	0.933	<.001	56	view →
STAD	DFS	Median	III,IV	0.248	0.455	.008	45	view →
THCA	OS	Tertile	All	0.938	0.992	.001	37	view →
ACC	DFS	Median	All	0.408	0.762	<.001	35	view →
PRAD	DFS	Median	All	0.834	0.937	<.001	32	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

STX1A–KIRC (DFS)

Open the KIRC breakdown →