STX1A

Across TCGA patient cohorts, STX1A mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STX1A-associated genes across cancer lineages are mTOR_pS2448, VHL, and Fibronectin. Each is linked with STX1A in more than 1 cancer types. Because this analysis shows association rather than direction, both STX1A-to-partner and partner-to-STX1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by STX1A-low versus STX1A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STX1A→partner) and Y-score (partner→STX1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.160	-2.302	.021	.034	3	2
UCEC	VHL →	-1.152	-2.321	<.001	.034	3	2
UCEC	Fibronectin →	-0.372	-3.312	.015	.010	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.537	+3.009	.023	.019	3	1
UCEC	MEK1 →	+0.500	+2.321	.003	.034	3	1
UCEC	eIF4E →	+0.258	+3.321	.008	.010	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

mTOR_pS2448 by STX1A expression — UCEC

Explore this box plot interactively →