STX1A

Across TCGA cell cohorts, STX1A mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible STX1A-associated genes across cancer lineages are TKTL2, SSMEM1, and NEXMIF. Each is linked with STX1A in more than 1 cancer types. Because this analysis shows association rather than direction, both STX1A-to-partner and partner-to-STX1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TKTL2 grouped by STX1A-low versus STX1A-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STX1A→partner) and Y-score (partner→STX1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TKTL2 →	+0.054	+4.187	<.001	.002	3	1
LARGE_INTESTINE	SSMEM1 →	+0.023	+3.766	.003	.004	3	1
LARGE_INTESTINE	NEXMIF →	+0.264	+3.196	<.001	.007	3	1
LARGE_INTESTINE	ADAM7 →	+0.004	+3.345	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

TKTL2 by STX1A expression — LARGE_INTESTINE

Explore this box plot interactively →