STX19

Across TCGA cell cohorts, STX19 mutation is significantly associated with the mutation status of many other genes, with 540 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible STX19-associated genes across cancer lineages are TLR1, UBXN7, and KLK7. Each is linked with STX19 in more than 2 cancer types. Because this analysis shows association rather than direction, both STX19-to-partner and partner-to-STX19 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TLR1 grouped by STX19-low versus STX19-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STX19→partner) and Y-score (partner→STX19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	TLR1 →	+4.239	+5.053	.007	.007	1	3
OVARY	UBXN7 →	+5.415	+5.415	.004	.004	1	2
OVARY	KLK7 →	+5.415	+5.415	.004	.004	1	2
OVARY	OSBPL5 →	+4.415	+4.977	.007	.007	1	2
SKIN	ZFP36L2 →	+5.824	+5.824	.002	.002	1	2
SKIN	ACTBL2 →	+5.824	+5.824	.002	.002	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 540 associations by consensus.

TLR1 by STX19 expression — SKIN

Explore this box plot interactively →